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Celexa is manufactured by Forest Pharmaceuticals, Inc.Lexapro (Escitalopram oxalate) is the newest and most selective of the SSRIs approved by the FDA in August 14, 2002. The brain communicates with itself through the use of special chemicals called neurotransmitters, such as serotonin and norepinephrine.The SSRIs represent the first rationally designed class of psychotropic medications.

Antidepressants have some different pharmacological characteristics, this means that patients may respond differently to certain SSRIs or experience different side effects with different drugs.

Nausea The most common side effect associated with use of SSRIs is nausea.

Paroxetine and sertraline have been associated with slightly more cases of nausea.

This leads to differences among the SSRIs in their half-lives, clinical activity, side effects, and drug interactions.

Certain differences between SSRIs are clinically significant.

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